Clinical trials in healthy volunteers and patients


Addressing the patient’s unmet medical need for many skin diseases is still one of the key challenges to overcome in dermatological research. Determined to tackle this challenge, LSI founding partner CHDR collaborates closely with key opinion leaders in dermatology, immunology, patient advocacy groups and other related academic fields.

Capabilities and solutions

At CHDR, we take a multi-faceted approach to pharmacology and dermatology. We investigate treatments for dermatological conditions such as psoriasis, eczema, allergic reactions, and inflammation, utilising advanced methods and biomarkers to objectively monitor clinical responses. Through these approaches, we can measure the effects of transdermal and intradermal drugs on the skin. Additionally, we study systemic conditions by evaluating skin responses, for example by measuring nerve fibre conduction, surface blood vessels, and local inflammation. Moreover, we are actively exploring ways to enhance wound healing.

The DermaToolbox

CHDR's DermaToolbox is a comprehensive battery of objective measurement tools designed to systematically quantify symptoms and assess the effects of new dermatological treatments. It includes a diverse range of advanced methods, such as Transepidermal Water Loss (TEWL), Laser Speckle Contrast Imaging (LSCI), Optical Coherence Tomography (OCT), Multispectral Imaging and high-definition 3D stereophotography. These techniques enable precise measurement of skin lesion dimensions, properties, and surface features.

Clinical network for Trials in Dermatology

We regularly conduct clinical trials in close collaboration with the Clinical Network for Trials in Dermatology (CONNECTED), a dynamic network of dermatologists with a shared passion for science and education. This expanding network now includes over 170 dermatologists from academic hospitals and peripheral clinics, with new members continually joining.

Our partnership with CONNECTED not only provides access to key opinion leaders in dermatology, but also enables rapid patient recruitment through referring dermatologists.

Hospitals involved in the network include, but are not limited to:

  • Leiden University Medical Center (LUMC)
  • Erasmus University Medical Center, Rotterdam
  • Amsterdam University Medical Centers (AUMCs)
  • Utrecht University Medical Center